Dysregulation of Semaphorin7A/b1-integrin signaling leads to defective GnRH-1 cell migration, abnormal gonadal development and altered fertility
نویسندگان
چکیده
Department of Human and Animal Biology, University of Turin, Turin 10123, Italy, Cellular and Developmental Neurobiology Section, NINDS, NIH, Bethesda, Maryland 20892, USA, Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, CG Utrecht 3584, The Netherlands and Inserm, Jean-Pierre Aubert Research Center, Unité 837, Development and Plasticity of the Postnatal Brain, Place de Verdun, Lille Cedex 59045, France
منابع مشابه
Dysregulation of Semaphorin7A/β1-integrin signaling leads to defective GnRH-1 cell migration, abnormal gonadal development and altered fertility.
Reproduction in mammals is dependent on the function of specific neurons that secrete gonadotropin-releasing hormone-1 (GnRH-1). These neurons originate prenatally in the nasal placode and migrate into the forebrain along the olfactory-vomeronasal nerves. Alterations in this migratory process lead to defective GnRH-1 secretion, resulting in heterogeneous genetic disorders such as idiopathic hyp...
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